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TENS PEMF therapy and Bacteria

The following studies represent some of the clinical evidence for the use of TENS PEMF therapy and Bacteria. Please note that these studies were not done on the Rife PEMF device, but rather represent studies including outputs which can be found on the various Rife Model MA devices.

For more information on TENS PEMF and bacteria, read PEMF therapy for Drug Resistant Conditions

TENS PEMF for Fatigue

Effects of 50 Hz Magnetic Fields on the Viability of Different Bacterial Strains The effect of a 50 Hz magnetic field on the growth of different bacterial strains was studied. We used bacteria with different cell shapes. We compared rod-shaped bacteria (E. coli, L. adecarboxylata) and spherical bacteria (S. aureus, P. denitrificans, S. paucimobilis, R. erythropolis). The growth curves of control and magnetic fields exposed samples were measured. The cylindrical coil induced magnetic fields with inductions up to 10 mT. Duration of exposure varied up to 24 min. Exposure took place at laboratory temperature (24–26°C) and the air ventilator maintained the temperature of sample. We observed the decrease of optical densities in exposed samples. The magnetic field effect was bigger for rod-like bacteria. 50Hz
Effect of extremely low frequency electromagnetic fields on bacterial membrane ELF-EMF caused changes in physicochemical properties of both Gram-positive and Gram-negative bacteria. Hyperpolarization was seen in S. aureus and EDTA-treated E. coli. Surface potential showed a positive shift in S. aureus contrariwise to the negative shift seen in EDTA-untreated E. coli. Respiratory activity increased in both bacteria. A slight decrease in growth was observed.  
The effects of different intensities, frequencies and exposure times of extremely low-frequency electromagnetic fields on the growth of Staphylococcus aureus and Escherichia coli Magnetic intensity, frequency and exposure time of ELF-EMFs changed the characteristic responses for both microorganisms. Samples exposed to ELF-EMF showed a statistically significant decrease compared to their controls in colony forming capability, especially at long exposure times. An exposure to 4 mT–20 Hz ELF-EMF of 6 h produced maximum inhibition of CFU compared to their controls for both microorganisms (95.2% for S. aureus and 85% for E. coli).  
Effects of low-frequency magnetic fields on bacteria Escherichia coli We observed analogous effects in both experimental conditions. The growth curve of the exposed bacteria was lower than the control one. The ability of bacteria to form colonies decreased with increasing magnetic field intensity and with increasing time of exposure. The decrease in oxidoreductive activity with increasing time of exposure was observed, but the effect was due to a lower amount of bacteria surviving the exposure to the magnetic fields. The decrease in oxidoreductive activity and ability to form colonies were compared with the assumption that the effect of magnetic field is probably bactericidal.  
Effects of extremely low-frequency electromagnetic fields on Helicobacter pylori biofilm.


The aim of this work was to investigate the effects of exposure to extremely low-frequency electromagnetic fields (ELF-EMF) both on biofilm formation and on mature biofilm of Helicobacter pylori. Bacterial cultures and 2-day-old biofilm of H. pylori ATCC 43629 were exposed to ELF-EMF (50 Hz frequency-1 mT intensity) for 2 days to assess their effect on the cell adhesion and on the mature biofilm detachment, respectively. All the exposed cultures and the respective sham exposed controls were studied for: the cell viability status, the cell morphological analysis, the biofilm mass measurement, the genotypic profile, and the luxS and amiA gene expression. The ELF-EMF acted on the bacterial population during the biofilm formation displaying significant differences in cell viability, as well as, in morphotypes measured by the prevalence of spiral forms (58.41%) in respect to the controls (33.14%), whereas, on mature biofilm, no significant differences were found when compared to the controls. The measurement of biofilm cell mass was significantly reduced in exposed cultures in both examined experimental conditions. No changes in DNA patterns were recorded, whereas a modulation in amiA gene expression was detected. An exposure to ELF-EMF of H. pylori biofilm induces phenotypic changes on adhering bacteria and decreases the cell adhesion unbalancing the bacterial population therefore reducing the H. pylori capability to protect itself.  

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TENS PEMF therapy in the management of ADD and ADHD

The following studies represent the clinical evidence for the use of TENS PEMF therapy in the management of ADD and ADHD. Please note these studies were not done on the Rife PEMF device, but do represent outputs available on our devices.

TENS PEMF therapy in the management of ADD and ADHD

For more information on ADHD and ADD, please read our article: TENS therapy for ADHD – ADHD Alternatives to medication

Effects of transcutaneous electrical nerve stimulation (TENS) on cognition, behavior, and the rest-activity rhythm in children with ADHD Twenty-two children diagnosed with ADHD-CT received TENS treatment during 6 weeks, 2 times 30 min a day. Neuropsychological tests were administered to assess cognition, parent/teacher behavioral rating scales were used to measure behavior, and actigraphy was used to assess the rest-activity rhythm. TENS appeared to have a moderate beneficial influence on cognitive functions that load particularly on executive function. There was also improvement in behavior as measured by parent/teacher behavioral rating scales. Moreover, motor restlessness during sleep and motor activity during the day decreased by TENS. CONCLUSIONS: The effects of TENS in children with ADHD are modest but encouraging and warrant further research.
Transcranial magnetic stimulation (TMS) in the treatment of attention-deficit/hyperactivity disorder in adolescents and young adults: a pilot study In 2012, Weaver et al. performed a pilot trial of 9 adolescents and young adults, age 15-20, using 10 Hz rTMS to the right dorsolateral prefrontal cortex 97. Subjects underwent 10 sessions over two weeks and each subject was crossed-over to receive sham. The objective of the study was to assess safety and the conclusion was that this was that rTMS was safe in this cohort, but the study was underpowered to show efficacy. Although the authors reported an improvement in core ADHD symptoms in the treatment group the effect did not differ significantly from the sham condition. 10Hz
Positive effects of repetitive transcranial magnetic stimulation on attention in ADHD Subjects: a randomized controlled pilot study. In 2010, Bloch et al. performed a double blind, randomized, sham controlled crossover pilot study with positive effects in 13 patients
Effectiveness of the repetitive Transcranical Magnetic Stimulation (rTMS) of 1 Hz for Attention-Deficit Hyperactivity Disorder (ADHD). The purpose of our study is to verify the therapeutic effectiveness of repetitive Transcranial Magnetic Stimulation (low frequency (1Hz, 1200 stim/die for five days)), applied on the impending scalp additional motor area, in a subject affected by ADHD. Results show a significant improvement that lasted for at least 4 weeks. Placebo control did not show any improvement. 1Hz
Saftey of TMS TMS has been used in over 800 normal children and over 300 neurologically abnormal children, with a good tolerability and safety profile 105,106. No change in auditory function has been reported in the pediatric population to date 105. Single- or paired-pulse TMS has not been shown to cause seizures in children, including those with epilepsy or with conditions like cerebral palsy that are associated with increased risk of seizures 101,107-113. One case of rTMS-induced seizure was reported in an adolescent patient being treated for depression 114, though other risk factors for seizure were also present, including alcohol use the night before the induced seizure 95. In 2009, a consensus conference issued recommendations for the safe use TMS in the pediatric population. They concluded that single-pulse and paired-pulse TMS was safe for children two years and older. In the absence of an appreciable volume of data on the potential for adverse effects with rTMS, they recommended that children should not be used as subjects for rTMS without compelling clinical reasons, such as the treatment of particular psychiatric conditions
Noninvasive Brain Stimulation in Pediatric ADHD: A Review An ongoing study is investigating the use of tDCS in adult patients with ADHD, which uses anodal tDCS stimulation over the left dorsolateral preftonal cortex at 1 mA127. The aim of this parallel, randomized, double-blind, sham-controlled trial is to study the modulation of inhibitory control in this population. While the results of tDCS in ADHD are not yet available there is a burgeoning literature suggesting that tDCS may be used to improve cognitive performance. These studies have shown that tDCS can improve behavioural inhibition, memory, and attention in healthy subjects 128,129, and these findings extend to clinical populations 127,130. There is reason to be optimistic that similar stimulation paradigms may have a beneficial effect for ADHD patients, though it will be critical that future studies be sufficiently powered and include a sham-controlled experimental design.
Transcranial direct current stimulation improves clinical symptoms in adolescents with attention deficit hyperactivity disorder Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has repeatedly been shown to improve working memory. As patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in working memory that correlate with clinical symptoms, it is hypothesized that the modulation of prefrontal activity with tDCS in patients with ADHD increases performance in working memory and reduces symptoms of ADHD. To test this hypothesis, fifteen adolescents with ADHD (12-16 years old, three girls and 12 boys) were treated according to the randomized, double-blinded, sham-controlled, crossover design with either 1 mA anodal tDCS over the left dorsolateral prefrontal cortex or with the sham protocol 5 days each with a 2 weeks pause between these conditions. Anodal tDCS caused a significant reduction in clinical symptoms of inattention and impulsivity in adolescents with ADHD compared to sham stimulation. The clinical effects were supported by a significant reduction in inattention and hyperactivity in a standardized working memory test (QbTest). The described effects were more pronounced 7 days after the end of stimulation, a fact which emphasizes the long-lasting clinical and neuropsychological changes after tDCS. This study provides the first evidence that tDCS may reduce symptoms of ADHD and improve neuropsychological functioning in adolescents and points on the potential of tDCS as a form of treatment for ADHD. 1 mA
Positive effects of transcranial direct current stimulation in adult patients with attention-deficit/hyperactivity disorder - A pilot randomized controlled study. We performed a double-blind, sham-controlled randomized clinical trial in 17 patients with ADHD. The set up for tDCS was the following: 2mA/20min/day for 5 days with the anode over the right dorsolateral prefrontal cortex and cathode over the left dorsolateral prefrontal cortex. ADHD symptoms were measured by the Adult ADHD Self-Report Scale (ASRS) and impairment with the Sheehan Disability Scale (SDS) in four different time points after stimulation. Participants achieved significant lower ASRS inattention and SDS scores after active tDCS in comparison with sham stimulation group. In addition, we detected a trend for a lower ASRS total score in the active tDCS group. Follow up data analysis revealed a positive interaction between time and treatment in both ASRS inattention, SDS and ASRS total scores. Short-term application of tDCS in adult patients with ADHD improved their symptoms, and this improvement persisted after the end of the stimulation. Future studies with larger sample sizes are needed. 2mA/20min/day

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TENS for Eyes

TENS for Eyes – Macular Degeneration

A new study on the effect of TENS for eyes in the form of micro-current stimulation has been published in the Journal of Clinical Ophthalmology in December 2015. TENS therapy for inflammation is starting to be accepted by mainstream medicine. TENS therapy is also being recognized for its benefits for circulation. TENS and PEMF therapy also offer other benefits like the promotion and support of wound healing and tissue regeneration. This study examines the effects of micro-current stimulation on age-related macular degeneration(AMD). Using plates placed over the eyes and applying micro-currents at various specific frequencies the study was aimed at working out if this form of therapy has any effect on dry and wet AMD.

TENS for Eyes

TENS for Eyes – Causes of Age-Related Macular Degeneration

Although the precise causes of AMD have yet to be identified, poor circulation or a decrease in circulation has been identified as a possible factor in the development of, and the progression of, age-related macular degeneration or AMD. Increasing the circulation can therefore be beneficial for those patients suffering from the condition.

Another factor that has been clearly identified as contributing factor to the condition is inflammation. TENS and PEMF are well known for their ability to reduce inflammation and they can therefore be valuable, non-invasive tools for supporting patients with macular degeneration.

TENS for Eyes – The study

Seventeen patients took part in this study. The age of the patients ranging between 67 and 95 years old. Each patient was selected based on their diagnosis of either wet or dry AMD by recognized eye clinics. 25 eyes in the study had been identified as being affected by dry AMD. 6 eyes in the study were identified as being affected by wet AMD.

Patients were given therapy once a week for thirty-five minutes using a specific range for frequencies. Each patient was monitored using Snellen Visual Acuity scales both before and after therapy.

The results of the study showed significant increases in visual acuity in both the dry and wet AMD eyes. With regards to the dry eye age-related macular degeneration, twice as many patients improved, and only slight deterioration was seen in the rest of the patients. Of these patients 52% of the patients improved with 26% showing decreased deterioration than would normally occur. In the wet eye group, five out of six eyes showed improvement and there was no deterioration.

The study concluded that the changes observed in the eyes were substantial and that further studies were warranted to determine the long term of effects of this type of treatment on AMD.

TENS for Eyes – A Non-invasive Approach

Since TENS and PEMF have relatively few adverse events and side-effects, and they are non-invasive therapies that one can use at home. These therapies may be worth trying for patients with AMD since there are few if any alternative therapies open to patients struggling with this condition at the moment.