PEMF therapy for Drug Resistant Conditions

PEMF therapy for drug resistant conditions may be a valuable adjunct to antibiotic therapy. According to a paper published in the South African Medical Journal in 2011, the incidence of drug resistant and multiple drug resistant conditions are increasing and placing a heavy burden on our health care system.[1] According to the report, “South Africa faces a quadruple burden of disease, as a result of the HIV/AIDS epidemic, other infectious diseases, injuries, and non-communicable diseases.”

If a therapy like PEMF therapy can help to reduce the number of drug resistant cases or reduce the treatment duration it takes to treat these patients, then the addition of frequency therapy could have a material impact on the health care budget and it would have a huge impact on patient quality of life.

PEMF therapy for drug resistant conditions

There is good scientific evidence that frequency therapy can impact the treatment of bacterial infections, particularly rod-shaped, gram positive bacteria.

There is also evidence that frequency therapy can improve the efficacy of antibiotics. This could mean that the addition of frequency therapy to current treatment options could result in a reduction in the treatment duration and necessary medication for the average drug resistant condition.

Frequency therapy is safe, non-invasive and cost-effective as a long-term treatment option.

The three main areas of interest which would need to be investigated further to assess PEMF therapy for drug resistant conditions would include:

  1. The potential bactericidal effects of frequency therapy
  2. The addition of frequency as an adjuvant therapy to assess if frequency therapy can improve treatment outcomes or reduce treatment duration
  3. The safety, cost, implementation and monitoring of frequency therapy in drug resistant conditions.

PEMF therapy for Drug Resistant Conditions – Evidence that frequency therapy has bactericidal effects

There are several studies that indicate that the use of extremely low frequency, electromagnetic fields (ELF-EMF) can impact the growth rate and viability of various types of bacteria. Summaries of this type of research include the following studies.

Researchers studied the effects of 50Hz at 10mT on rod-shaped E. coli and L. adecarboxylata, as well as spherical shaped S. aureus, P. denitrificans, S. paucimobilis and R. erythropolis. Growth curves were measured in exposed and control samples and decreases in optical densities of the bacteria were observed for exposed samples. Researchers concluded that ELF-EMF reduced growth rate of the bacteria and the magnetic field effect was larger for rod shaped bacteria. [2]

In a study published in the International Journal of Radiation Biology, researchers studied the effects of ELF-EMF fields of less than 300Hz on the growth rate and morphological changes on 6 different strains of gram positive and gram-negative bacteria. Bacteria were exposed to 50Hz at 0.5mT and growth rates were determined by optical density measurements made every hour. The study concluded that ELF-EMF induced a decrease in growth rate and morphological changes for both Gram-negative and Gram-positive bacteria.[3]

The effects of different Hz values of ELF Pulsed electromagnetic fields (ELF-PEMF) were studied with regards to their effects on bacterial survival of E.Coli. The viability of E. coli was measured as colony-forming units (CFUs) before and after the exposures at frequencies between 2–500 Hz and magnetic flux densities between 2.5–5 mT. The study found that the maximum reduction in bacterial growth was observed with the exposures at 3 Hz and 0.5 mT. The maximum decrease in CFU was recorded for the exposure at 500 Hz and 2.5 mT, which corresponded to a relative decrease of 77.26% in the bacterial growth. The study concluded that the findings have direct implication for determining the optimal characteristics of the applied ELF PEMF for possible treatment of infected tissue and thus, wound healing promotion.[4]

In a study on the growth inhibition of Staphylococcus aureus induced by ELF-EMF fields, researchers exposed cultures of Staphylococcus aureus in fluid and gel‐like medium to a low‐frequency electromagnetic field, an electromagnetic field combined with an additional electric field, a sinusoidal electric field and a static electric field. Researchers recorded that Staphylococcus aureus concentrations in fluid medium could clearly be reduced under the influence of the four different applied fields within 24 h of experiment. The strongest effects were observed for the direct current electric field which could decrease CFU/ml of 37%, and the low‐frequency electromagnetic field with additional induced electric alternating field with a decrease of Staphylococci concentration by 36%.[5]

Studies have also been done on the effects of ELF-EMF and its ability to affect the biofilms of bacteria. One study on the effects of ELF-EMF fields on Helicobacter pylori biofilm found that exposure to 50 Hz frequency-1 mT intensity resulted in biofilm cell mass that was significantly reduced in exposed cultures. The study concluded that exposure to ELF-EMF of H. pylori biofilm induced phenotypic changes on adhering bacteria. It decreased the cell adhesion unbalancing the bacterial population, and it therefore reduced the bacteria’s capability to protect itself.[6]

In summary, the above studies all form a strong foundation for the belief that the addition of ELF-EMF therapy to drug resistant conditions could positively affect therapy outcomes due to the bactericidal effects of frequency therapy.

PEMF therapy for Drug Resistant Conditions – Frequency as an adjuvant therapy to improve treatment Outcomes

Frequency therapy has not only been studied for its bactericidal effects but has also been studied to enhance or improve antibiotic efficacy and has even been shown to help combat drug resistance in certain cases.

Researchers studied the effect of electromagnetic augmentation of two types of antibiotics in reducing infections of orthopedic implants. They grew five-day biofilms of Staphylococcus epidermidis on the tips of stainless-steel pegs. The pegs were exposed for 12 hours to varying concentrations of gentamicin or vancomycin in microtiter trays at 37 degrees and to pulsed electromagnetic fields. The study found that PEMF’s increased the effects of gentamicin. In three of five experiments there was reduction of at least 50% in the minimum biofilm inhibitory concentration. In a fourth experiment there was a two-log difference in colony count at 160 mg/l of gentamicin.[7]

Augmentation of antibiotic activity of gentamicin was also studied in the treatment of Staphylococcus aureus. Four separate experimental setups were used to expose bacterial cultures of Staphylococcus aureus both in Mueller-Hinton broth (MHB) and on Mueller-Hinton agar (MHA), in the presence of gentamicin. In MHB each of the four fields applied showed a significant growth reduction of planktonically grown Staphylococcus aureus in the presence of gentamicin between 32% and 91% within 24 h of the experiment. The best results were obtained by a direct current EF, decreasing colony-forming units (CFU)/ml more than 91%. The study concluded that the application of electromagnetic fields in implant and bone infections could offer new perspectives in antibiotic treatment and antimicrobial chemotherapy.[8]

In another study, researchers studied the potential drug resistance modification effects of PEMF stimulation in multidrug resistant mouse osteosarcoma. PEMF stimulation reversed doxorubicin resistance. The concluded that PEMFs reversed the doxorubicin resistance of the MOS/ADR1 cells by inhibiting P-gp function. The results suggested that PEMFs may be useful as a local treatment for MDR osteosarcoma.[9]

Finally, researchers explored the effects of pre-exposure to 50Hz to help to reduce resistance to 5-fluorouracil to enhance efficacy of the drug. The study explored the combined effect of 50 Hz-EMFs and 5-FU in the treatment of breast cancer. Researchers found that pre-exposure to 50 Hz-EMFs enhanced the antiproliferative effect of 5-FU in breast cancer cell line MCF-7 in a dose-dependent manner but did not affect normal human breast epithelial cell lines. They concluded that the enhanced cytotoxic activity of 5-FU on MCF7 cells through promoting entry into the S phase of the cell cycle via exposure to 50 Hz-EMFs, may provide a novel method of cancer treatment based on the combinatorial use of 50 Hz-EMFs and chemotherapy.[10]

The above studies indicated that ELF-EMFs and frequency therapy could potentially offer a novel approach to combatting drug resistant drug resistant conditions through the addition of frequency therapy as an adjuvant therapy in conjunction with conventional medication.

PEMF therapy for Drug Resistant Conditions – Safety, cost, implementation and monitoring of frequency therapy in drug resistant conditions

Naturally, before any therapy could be considered as an adjuvant therapy for any condition, it is imperative to examine the safety aspects of the proposed therapy.

Frequency therapy in the form of ELF-EMF, TENS and PEMF have been studied across a wide range of conditions for decades. There are even studies indicating that PEMF therapy for drug resistant cancers may be a viable option. For more information on that read “Pemf therapy for drug resistant cancer.”

These studies provide us with some information on the safety concerns and considerations for PEMF therapy for drug resistant conditions. Studies we have gathered over the years indicate that PEMF and frequency therapy have an exemplary safety profile with thousands of studies concluding no adverse effects from the therapy and minimal side effects associated with this type of treatment.

Dr Pawluk, an authority on PEMF therapy had the following remarks regarding the safety of PEMF therapy:

“There are only a few FDA-approved PEMF systems on the market. The primary mandate of the FDA is to ensure safety – even before proving efficacy of treatment. So keeping that in mind, we can examine the treatment parameters for one such FDA-approved PEMF system, the NeuroStar. This system (which uses the acronym TMS – transcranial magnetic stimulation – instead of PEMF) is indicated for Major Depressive Disorder and is an extremely high intensity system with stimulation aimed directly at the brain. NeuroStar systems produce intensities comparable to those of an MRI machine. …. Average treatment sessions last for 45 minutes. In NeuroStar clinical trials, more than 10,000 treatments were administered with no occurrence of adverse side effects.

So, this is extremely high intensity PEMF therapy applied directly to the head, and it is proven to be safe. These intensities are much higher than those of most commercially-available PEMF systems.”

With regards to seizures, Dr Pawluk states that:

“As long as I’ve been working with PEMFs there has always been a concern that PEMFs may cause seizures. There is now a fairly large body of research regarding the use of PEMFs of different intensities and the potential association with seizures. Evidence indicates that PEMFs are very unlikely to cause seizures. This is comes from research studies using high-intensity PEMF systems, which have the highest concern for generating seizure activity. In fact, studies that not only are PEMFs not at all likely to induce a seizure, they are capable of providing benefit to epileptic patients”[11]

Considering the safety profile of ELF-EMF therapy, the other considerations that need to be taken into account include the cost, implementation and monitoring of PEMF therapy for drug resistant conditions.

PEMF therapy for Drug Resistant Conditions – Cost and implementation of PEMF therapy

The current Rife PEMF Model MA200 can be used for the preliminary investigations to determine if this type of therapy can provide the benefits outlined above of reduced treatment duration and combatting drug resistance.

The stainless-steel cylinders that are provided with the device make implementation of the therapy simple and they provide the opportunity to sterilize equipment between patients, to reduce the chances of cross-contamination.

The Model MA200 can be rented for R499 per month, making it a cost-effective addition to therapy.

PEMF therapy for Drug Resistant Conditions – Conclusion

Frequency therapy has been shown to offer bactericidal effects, it has also been shown to help enhance antibiotic efficacy, and it has been shown to combat drug resistance. PEMF therapy for drug resistant conditions could therefore be helpful as an additional therapy option.

South Africa has been shown to take the lead in drug resistant conditions therapy by implementing mass roll out of bedaquiline to help combat drug resistant TB. The addition of frequency therapy to the drug resistant conditions treatment regimen may also be a world-first if it is shown to improve the treatment outcomes of drug resistant conditions.

The technology is locally owned, developed and produced providing South Africa with a huge potential advantage in the fight against multidrug resistant drug resistant conditions and potentially allowing South Africa to be a true leader in the fight against drug resistant conditions locally and perhaps even globally.

If investigations are successful, PEMF therapy for drug resistant conditions could be a reality in the near future.

[1] http://www.samj.org.za/index.php/samj/article/view/5102/3367

[2] https://doi.org/10.1080/15368370500379715

[3] https://www.ncbi.nlm.nih.gov/pubmed/21401315

[4] https://www.tandfonline.com/doi/full/10.1080/09205071.2014.974684?scroll=top&needAccess=true

[5] https://doi.org/10.1002/bem.20479

[6] https://www.ncbi.nlm.nih.gov/pubmed/?term=20033173

[7] https://www.ncbi.nlm.nih.gov/pubmed/12793569

[8] https://www.ncbi.nlm.nih.gov/pubmed/21437921

[9] https://www.ncbi.nlm.nih.gov/pubmed/11299755

[10] https://www.ncbi.nlm.nih.gov/pubmed/29617363

[11] https://www.drpawluk.com/education/pemf-information/pemf-safety/

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