Category Archives: PEMF Research

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PEMF therapy for Candida and Drug Resistant Candida

New studies suggest that PEMF therapy for candida and drug resistant candida can be a valuable addition as an adjuvant therapy for patients struggling with candida and other fungal based infections.

According to an article published in the Journal of Preventative Medicine, published in 2012, infections due to Candida have seen a dramatic increase, partially due to the increase in immunocompromised patients. Feedback from our practitioners has to a certain extent reflected this increase in fungal and candida infections.

PEMF therapy for Candida and Drug Resistant Candida

Interestingly enough, there are studies that indicate that PEMF therapy may be added to other therapies and medications to help to address the issue.

PEMF Therapy for Candida – Research

There are numerous studies which deal with the effects of Pulsed electromagnetic fields on various types of fungal infections. Pulsed electric and pulsed electromagnetic fields have even been shown to have potential applications in other industries such as the wine and fruit juice industries where PEF’s were shown to reduce fungal growth and thereby prevent spoilage of products.

In terms of biological applications, we would like to focus on the following studies:

In a study focused on Trichophyton rubrum, a fungal infection most often responsible for athlete's foot, fungal infection of nail, jock itch, and ringworm, researchers found that pulsed electric fields of 1Hz, in combination with antifungal medications itraconazole, terbinafine, and naftifine HCl, in the study case, resulted in full inactivation of the T. Rubrum colonies studied.[1]

Another study, focused on researching the influence of PH and the use of pulsed electric fields in combination with medication to help the sensitization of drug resistant strains of candida to antifungal drugs. This study found that PEF at a low pH increased the sensitivity of initially resistance C. Albicans to terbinafine and naftifine[2].

And finally, a study done on 15 strains of candida, isolated from patients, were tested for their susceptibility to miconazole after exposure to electromagnetic fields. The study showed that an increased susceptibility to miconazole occurred from the second week of exposure to electromagnetic fields of 3Hz and 12.5Hz at a strength of 2mT and 9mT. The study concluded that low frequency PEMF for a period of at least two weeks, in conjunction with miconazole, could possibly be beneficial for the treatment of Candida.[3]

PEMF Therapy for Candida - Candida Programs on the MA Home and MA Clinic Devices

The MA Home and MA Clinic devices both contain programs for the use in treating the pain of Candida. For the latest Candida protocol, please feel free to contact us for access to our latest protocols. Considering the safety profile of PEMF therapy, there is no harm adding the Candida programs to your regular patient PEMF therapy.

Based on the links between autoimmune diseases and candida, it may also be beneficial to add the candida programs or protocols to your therapy programs for your autoimmune patients. And based on the studies above, adding PEMF therapy for Candida in patients struggling with the condition, it may turn out to be a very valuable addition to your treatment protocols.

[1] Controlled inactivation of Trichophyton rubrum using shaped electrical pulse bursts: Parametric analysis

[2] Pulsed electric field-assisted sensitization of multidrug-resistant Candida albicans to antifungal drugs.

[3] Effect of electromagnetic waves on sensitivity of fungi of the genus Candida to miconazole.


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TENS PEMF therapy and Bacteria

The following studies represent some of the clinical evidence for the use of TENS PEMF therapy and Bacteria. Please note that these studies were not done on the Rife PEMF device, but rather represent studies including outputs which can be found on the various Rife Model MA devices.

For more information on TENS PEMF and bacteria, read PEMF therapy for Drug Resistant Conditions

TENS PEMF for Fatigue

Effects of 50 Hz Magnetic Fields on the Viability of Different Bacterial Strains The effect of a 50 Hz magnetic field on the growth of different bacterial strains was studied. We used bacteria with different cell shapes. We compared rod-shaped bacteria (E. coli, L. adecarboxylata) and spherical bacteria (S. aureus, P. denitrificans, S. paucimobilis, R. erythropolis). The growth curves of control and magnetic fields exposed samples were measured. The cylindrical coil induced magnetic fields with inductions up to 10 mT. Duration of exposure varied up to 24 min. Exposure took place at laboratory temperature (24–26°C) and the air ventilator maintained the temperature of sample. We observed the decrease of optical densities in exposed samples. The magnetic field effect was bigger for rod-like bacteria. 50Hz
Effect of extremely low frequency electromagnetic fields on bacterial membrane ELF-EMF caused changes in physicochemical properties of both Gram-positive and Gram-negative bacteria. Hyperpolarization was seen in S. aureus and EDTA-treated E. coli. Surface potential showed a positive shift in S. aureus contrariwise to the negative shift seen in EDTA-untreated E. coli. Respiratory activity increased in both bacteria. A slight decrease in growth was observed.  
The effects of different intensities, frequencies and exposure times of extremely low-frequency electromagnetic fields on the growth of Staphylococcus aureus and Escherichia coli Magnetic intensity, frequency and exposure time of ELF-EMFs changed the characteristic responses for both microorganisms. Samples exposed to ELF-EMF showed a statistically significant decrease compared to their controls in colony forming capability, especially at long exposure times. An exposure to 4 mT–20 Hz ELF-EMF of 6 h produced maximum inhibition of CFU compared to their controls for both microorganisms (95.2% for S. aureus and 85% for E. coli).  
Effects of low-frequency magnetic fields on bacteria Escherichia coli We observed analogous effects in both experimental conditions. The growth curve of the exposed bacteria was lower than the control one. The ability of bacteria to form colonies decreased with increasing magnetic field intensity and with increasing time of exposure. The decrease in oxidoreductive activity with increasing time of exposure was observed, but the effect was due to a lower amount of bacteria surviving the exposure to the magnetic fields. The decrease in oxidoreductive activity and ability to form colonies were compared with the assumption that the effect of magnetic field is probably bactericidal.  
Effects of extremely low-frequency electromagnetic fields on Helicobacter pylori biofilm.

 

The aim of this work was to investigate the effects of exposure to extremely low-frequency electromagnetic fields (ELF-EMF) both on biofilm formation and on mature biofilm of Helicobacter pylori. Bacterial cultures and 2-day-old biofilm of H. pylori ATCC 43629 were exposed to ELF-EMF (50 Hz frequency-1 mT intensity) for 2 days to assess their effect on the cell adhesion and on the mature biofilm detachment, respectively. All the exposed cultures and the respective sham exposed controls were studied for: the cell viability status, the cell morphological analysis, the biofilm mass measurement, the genotypic profile, and the luxS and amiA gene expression. The ELF-EMF acted on the bacterial population during the biofilm formation displaying significant differences in cell viability, as well as, in morphotypes measured by the prevalence of spiral forms (58.41%) in respect to the controls (33.14%), whereas, on mature biofilm, no significant differences were found when compared to the controls. The measurement of biofilm cell mass was significantly reduced in exposed cultures in both examined experimental conditions. No changes in DNA patterns were recorded, whereas a modulation in amiA gene expression was detected. An exposure to ELF-EMF of H. pylori biofilm induces phenotypic changes on adhering bacteria and decreases the cell adhesion unbalancing the bacterial population therefore reducing the H. pylori capability to protect itself.  

For more information, research and studies on TENS PEMF therapy and Bacteria, please join our newsletter or check back regularly for updates.


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TENS PEMF therapy in the management of ADD and ADHD

The following studies represent the clinical evidence for the use of TENS PEMF therapy in the management of ADD and ADHD. Please note these studies were not done on the Rife PEMF device, but do represent outputs available on our devices.

TENS PEMF therapy in the management of ADD and ADHD

For more information on ADHD and ADD, please read our article: TENS therapy for ADHD – ADHD Alternatives to medication

Effects of transcutaneous electrical nerve stimulation (TENS) on cognition, behavior, and the rest-activity rhythm in children with ADHD Twenty-two children diagnosed with ADHD-CT received TENS treatment during 6 weeks, 2 times 30 min a day. Neuropsychological tests were administered to assess cognition, parent/teacher behavioral rating scales were used to measure behavior, and actigraphy was used to assess the rest-activity rhythm. TENS appeared to have a moderate beneficial influence on cognitive functions that load particularly on executive function. There was also improvement in behavior as measured by parent/teacher behavioral rating scales. Moreover, motor restlessness during sleep and motor activity during the day decreased by TENS. CONCLUSIONS: The effects of TENS in children with ADHD are modest but encouraging and warrant further research.
Transcranial magnetic stimulation (TMS) in the treatment of attention-deficit/hyperactivity disorder in adolescents and young adults: a pilot study In 2012, Weaver et al. performed a pilot trial of 9 adolescents and young adults, age 15-20, using 10 Hz rTMS to the right dorsolateral prefrontal cortex 97. Subjects underwent 10 sessions over two weeks and each subject was crossed-over to receive sham. The objective of the study was to assess safety and the conclusion was that this was that rTMS was safe in this cohort, but the study was underpowered to show efficacy. Although the authors reported an improvement in core ADHD symptoms in the treatment group the effect did not differ significantly from the sham condition. 10Hz
Positive effects of repetitive transcranial magnetic stimulation on attention in ADHD Subjects: a randomized controlled pilot study. In 2010, Bloch et al. performed a double blind, randomized, sham controlled crossover pilot study with positive effects in 13 patients
Effectiveness of the repetitive Transcranical Magnetic Stimulation (rTMS) of 1 Hz for Attention-Deficit Hyperactivity Disorder (ADHD). The purpose of our study is to verify the therapeutic effectiveness of repetitive Transcranial Magnetic Stimulation (low frequency (1Hz, 1200 stim/die for five days)), applied on the impending scalp additional motor area, in a subject affected by ADHD. Results show a significant improvement that lasted for at least 4 weeks. Placebo control did not show any improvement. 1Hz
Saftey of TMS TMS has been used in over 800 normal children and over 300 neurologically abnormal children, with a good tolerability and safety profile 105,106. No change in auditory function has been reported in the pediatric population to date 105. Single- or paired-pulse TMS has not been shown to cause seizures in children, including those with epilepsy or with conditions like cerebral palsy that are associated with increased risk of seizures 101,107-113. One case of rTMS-induced seizure was reported in an adolescent patient being treated for depression 114, though other risk factors for seizure were also present, including alcohol use the night before the induced seizure 95. In 2009, a consensus conference issued recommendations for the safe use TMS in the pediatric population. They concluded that single-pulse and paired-pulse TMS was safe for children two years and older. In the absence of an appreciable volume of data on the potential for adverse effects with rTMS, they recommended that children should not be used as subjects for rTMS without compelling clinical reasons, such as the treatment of particular psychiatric conditions
Noninvasive Brain Stimulation in Pediatric ADHD: A Review An ongoing study is investigating the use of tDCS in adult patients with ADHD, which uses anodal tDCS stimulation over the left dorsolateral preftonal cortex at 1 mA127. The aim of this parallel, randomized, double-blind, sham-controlled trial is to study the modulation of inhibitory control in this population. While the results of tDCS in ADHD are not yet available there is a burgeoning literature suggesting that tDCS may be used to improve cognitive performance. These studies have shown that tDCS can improve behavioural inhibition, memory, and attention in healthy subjects 128,129, and these findings extend to clinical populations 127,130. There is reason to be optimistic that similar stimulation paradigms may have a beneficial effect for ADHD patients, though it will be critical that future studies be sufficiently powered and include a sham-controlled experimental design.
Transcranial direct current stimulation improves clinical symptoms in adolescents with attention deficit hyperactivity disorder Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has repeatedly been shown to improve working memory. As patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in working memory that correlate with clinical symptoms, it is hypothesized that the modulation of prefrontal activity with tDCS in patients with ADHD increases performance in working memory and reduces symptoms of ADHD. To test this hypothesis, fifteen adolescents with ADHD (12-16 years old, three girls and 12 boys) were treated according to the randomized, double-blinded, sham-controlled, crossover design with either 1 mA anodal tDCS over the left dorsolateral prefrontal cortex or with the sham protocol 5 days each with a 2 weeks pause between these conditions. Anodal tDCS caused a significant reduction in clinical symptoms of inattention and impulsivity in adolescents with ADHD compared to sham stimulation. The clinical effects were supported by a significant reduction in inattention and hyperactivity in a standardized working memory test (QbTest). The described effects were more pronounced 7 days after the end of stimulation, a fact which emphasizes the long-lasting clinical and neuropsychological changes after tDCS. This study provides the first evidence that tDCS may reduce symptoms of ADHD and improve neuropsychological functioning in adolescents and points on the potential of tDCS as a form of treatment for ADHD. 1 mA
Positive effects of transcranial direct current stimulation in adult patients with attention-deficit/hyperactivity disorder - A pilot randomized controlled study. We performed a double-blind, sham-controlled randomized clinical trial in 17 patients with ADHD. The set up for tDCS was the following: 2mA/20min/day for 5 days with the anode over the right dorsolateral prefrontal cortex and cathode over the left dorsolateral prefrontal cortex. ADHD symptoms were measured by the Adult ADHD Self-Report Scale (ASRS) and impairment with the Sheehan Disability Scale (SDS) in four different time points after stimulation. Participants achieved significant lower ASRS inattention and SDS scores after active tDCS in comparison with sham stimulation group. In addition, we detected a trend for a lower ASRS total score in the active tDCS group. Follow up data analysis revealed a positive interaction between time and treatment in both ASRS inattention, SDS and ASRS total scores. Short-term application of tDCS in adult patients with ADHD improved their symptoms, and this improvement persisted after the end of the stimulation. Future studies with larger sample sizes are needed. 2mA/20min/day

To keep up to date on the latest studies, and clinical evidence for TENS PEMF therapy in the management of ADD and ADHD, please feel free to join our newsletter, or check back periodically.


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PEMF TENS for Alzheimer disease – Research Updates

The aim of this article on PEMF TENS for Alzheimer disease is provide a simple review of the studies on the effects of electrotherapy including the effects of PEMF TENS therapy for Alzheimer’s disease.

PEMF TENS for Alzheimer’s disease

PEMF TENS for Alzheimer’s disease

This review contains 10 studies related to electrotherapy and the symptoms, progression and prognosis of Alzheimer disease. The review is not intended as an exhaustive list of studies in this area.

For an article on how PEMF TENS for Alzheimer disease can benefit patients, please feel free to read our article, “How PEMF therapy benefits Alzheimer disease.” For information on how HSV1 and the herpes virus can impact Alzheimer patients, please read our article: "PEMF TENS Alzheimer Update: The Alzheimer HSV1 link".

List of studies on PEMF TENS for Alzheimer Disease:

1.         Temporal cortex direct current stimulation enhances visual recognition in Alzheimer’s Disease Link The results showed a significant effect of stimulation condition on VRM (p = 0.0085), and post hoc analysis showed an improvement after temporal (p = 0.01) and prefrontal (p = 0.01) tDCS as compared with sham stimulation. There were no significant changes in attention as indexed by Stroop task performance. As far as is known, this is the first trial showing that tDCS can enhance a component of recognition memory 2 mA
2.         Prolonged visual memory enhancement after direct current stimulation in Alzheimer's disease Link After patients received tDCS, their performance in a visual recognition memory test significantly improved. We found a main effect of tDCS on memory performance, i.e., anodal stimulation improved it by 8.99% from baseline, whereas sham stimulation decreased it by 2.62%. tDCS failed to influence differentially general cognitive performance measures or a visual attention measure 2 mA intensity delivered for 30 minutes per day for 5 consecutive days.
3.         Transcranial direct current stimulation improves recognition memory in Alzheimer disease. Link Transcranial direct current stimulation (tDCS) delivered over the temporoparietal areas can specifically affect a recognition memory performance in patients with Alzheimer disease (AD). Because tDCS is simple, safe and inexpensive, our finding prompts studies using repeated tDCS, in conjunction with other therapeutic interventions for treating patients with AD. Unkown
4.         tDCS alongside picture training improves naming scores in Anomic dementia Link Patients treated and giving training improved 10% and 7 % over patients given no training or treatment 10 sessions 2mA over 3 weeks
5.         rTMS as a treatment for Alzheimer’s Patients who received rTMS in early stages of Alzheimer’s disease showed noticeably stronger improvement during treatment sessions 20Hz 2 second intervals
6.         Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer’s Disease anodal tDCS benefits in AD patients during working memory tasks are supported by the modulation of cortical activity 1.5mA intensity for 15 min over bilateral TP areas
7.         At-home tDCS of the left dorsolateral prefrontal cortex improves visual short-term memory in mild vascular dementia. Link In patients with mild vascular dementia, anodal tDCS of the left DLPFC is able to produce additional effects to cognitive training on visual short-term memory, verbal working memory, and executive control. 2mA 20 minute sessions
8.         Alzheimer's disease: improvement of visual memory and visuoconstructive performance by treatment with picotesla range magnetic fields Link The report demonstrates, for the first time, that specific cognitive symptoms of AD are improved by treatment with EMF of a specific intensity and frequency. The rapid improvement in cognitive functions in response to EMF suggests that some of the mental deficits of AD are reversible being caused by a functional (i.e., synaptic transmission) rather than a structural (i.e., neuritic plaques) disruption of neuronal communication in the central nervous system. the range of 5Hz-8Hz
9.         Value and Efficacy of Transcranial Direct Current Stimulation in the Cognitive Rehabilitation: A Critical Review Since 2000 Link … “most of the studies reviewed reported a positive

Effect of tDCS in all these neurocognitive disorders”

Various
10.     Adjunctive treatment with high frequency repetitive

transcranial magnetic stimulation for the behavioral and

psychological symptoms of patients with Alzheimer’s disease:

a randomized, double-blind, sham-controlled study
Link

Conclusion: Compared to treatment of AD with low-dose antipsychotic medications alone, the combination

of low-dose antipsychotic medication with adjunctive treatment with high frequency rTMS can significantly

improve both cognitive functioning and the behavioral and psychological symptoms that often accompany

Alzheimer’s disease.

20Hz rTMS five days a week for four weeks

Please also see our protocol for Alzheimer disease here: Protocol for PEMF TENS for Alzheimer disease

Click here to reserve your Model MA200 or MA700 today


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PEMF therapy for drug resistant cancer

PEMF therapy for Drug Resistant Conditions

PEMF therapy for drug resistant conditions may be a valuable adjunct to antibiotic therapy. According to a paper published in the South African Medical Journal in 2011, the incidence of drug resistant and multiple drug resistant conditions are increasing and placing a heavy burden on our health care system.[1] According to the report, “South Africa faces a quadruple burden of disease, as a result of the HIV/AIDS epidemic, other infectious diseases, injuries, and non-communicable diseases.”

If a therapy like PEMF therapy can help to reduce the number of drug resistant cases or reduce the treatment duration it takes to treat these patients, then the addition of frequency therapy could have a material impact on the health care budget and it would have a huge impact on patient quality of life.

PEMF therapy for drug resistant conditions

There is good scientific evidence that frequency therapy can impact the treatment of bacterial infections, particularly rod-shaped, gram positive bacteria.

There is also evidence that frequency therapy can improve the efficacy of antibiotics. This could mean that the addition of frequency therapy to current treatment options could result in a reduction in the treatment duration and necessary medication for the average drug resistant condition.

Frequency therapy is safe, non-invasive and cost-effective as a long-term treatment option.

The three main areas of interest which would need to be investigated further to assess PEMF therapy for drug resistant conditions would include:

  1. The potential bactericidal effects of frequency therapy
  2. The addition of frequency as an adjuvant therapy to assess if frequency therapy can improve treatment outcomes or reduce treatment duration
  3. The safety, cost, implementation and monitoring of frequency therapy in drug resistant conditions.

PEMF therapy for Drug Resistant Conditions – Evidence that frequency therapy has bactericidal effects

There are several studies that indicate that the use of extremely low frequency, electromagnetic fields (ELF-EMF) can impact the growth rate and viability of various types of bacteria. Summaries of this type of research include the following studies.

Researchers studied the effects of 50Hz at 10mT on rod-shaped E. coli and L. adecarboxylata, as well as spherical shaped S. aureus, P. denitrificans, S. paucimobilis and R. erythropolis. Growth curves were measured in exposed and control samples and decreases in optical densities of the bacteria were observed for exposed samples. Researchers concluded that ELF-EMF reduced growth rate of the bacteria and the magnetic field effect was larger for rod shaped bacteria. [2]

In a study published in the International Journal of Radiation Biology, researchers studied the effects of ELF-EMF fields of less than 300Hz on the growth rate and morphological changes on 6 different strains of gram positive and gram-negative bacteria. Bacteria were exposed to 50Hz at 0.5mT and growth rates were determined by optical density measurements made every hour. The study concluded that ELF-EMF induced a decrease in growth rate and morphological changes for both Gram-negative and Gram-positive bacteria.[3]

The effects of different Hz values of ELF Pulsed electromagnetic fields (ELF-PEMF) were studied with regards to their effects on bacterial survival of E.Coli. The viability of E. coli was measured as colony-forming units (CFUs) before and after the exposures at frequencies between 2–500 Hz and magnetic flux densities between 2.5–5 mT. The study found that the maximum reduction in bacterial growth was observed with the exposures at 3 Hz and 0.5 mT. The maximum decrease in CFU was recorded for the exposure at 500 Hz and 2.5 mT, which corresponded to a relative decrease of 77.26% in the bacterial growth. The study concluded that the findings have direct implication for determining the optimal characteristics of the applied ELF PEMF for possible treatment of infected tissue and thus, wound healing promotion.[4]

In a study on the growth inhibition of Staphylococcus aureus induced by ELF-EMF fields, researchers exposed cultures of Staphylococcus aureus in fluid and gel‐like medium to a low‐frequency electromagnetic field, an electromagnetic field combined with an additional electric field, a sinusoidal electric field and a static electric field. Researchers recorded that Staphylococcus aureus concentrations in fluid medium could clearly be reduced under the influence of the four different applied fields within 24 h of experiment. The strongest effects were observed for the direct current electric field which could decrease CFU/ml of 37%, and the low‐frequency electromagnetic field with additional induced electric alternating field with a decrease of Staphylococci concentration by 36%.[5]

Studies have also been done on the effects of ELF-EMF and its ability to affect the biofilms of bacteria. One study on the effects of ELF-EMF fields on Helicobacter pylori biofilm found that exposure to 50 Hz frequency-1 mT intensity resulted in biofilm cell mass that was significantly reduced in exposed cultures. The study concluded that exposure to ELF-EMF of H. pylori biofilm induced phenotypic changes on adhering bacteria. It decreased the cell adhesion unbalancing the bacterial population, and it therefore reduced the bacteria’s capability to protect itself.[6]

In summary, the above studies all form a strong foundation for the belief that the addition of ELF-EMF therapy to drug resistant conditions could positively affect therapy outcomes due to the bactericidal effects of frequency therapy.

PEMF therapy for Drug Resistant Conditions – Frequency as an adjuvant therapy to improve treatment Outcomes

Frequency therapy has not only been studied for its bactericidal effects but has also been studied to enhance or improve antibiotic efficacy and has even been shown to help combat drug resistance in certain cases.

Researchers studied the effect of electromagnetic augmentation of two types of antibiotics in reducing infections of orthopedic implants. They grew five-day biofilms of Staphylococcus epidermidis on the tips of stainless-steel pegs. The pegs were exposed for 12 hours to varying concentrations of gentamicin or vancomycin in microtiter trays at 37 degrees and to pulsed electromagnetic fields. The study found that PEMF’s increased the effects of gentamicin. In three of five experiments there was reduction of at least 50% in the minimum biofilm inhibitory concentration. In a fourth experiment there was a two-log difference in colony count at 160 mg/l of gentamicin.[7]

Augmentation of antibiotic activity of gentamicin was also studied in the treatment of Staphylococcus aureus. Four separate experimental setups were used to expose bacterial cultures of Staphylococcus aureus both in Mueller-Hinton broth (MHB) and on Mueller-Hinton agar (MHA), in the presence of gentamicin. In MHB each of the four fields applied showed a significant growth reduction of planktonically grown Staphylococcus aureus in the presence of gentamicin between 32% and 91% within 24 h of the experiment. The best results were obtained by a direct current EF, decreasing colony-forming units (CFU)/ml more than 91%. The study concluded that the application of electromagnetic fields in implant and bone infections could offer new perspectives in antibiotic treatment and antimicrobial chemotherapy.[8]

In another study, researchers studied the potential drug resistance modification effects of PEMF stimulation in multidrug resistant mouse osteosarcoma. PEMF stimulation reversed doxorubicin resistance. The concluded that PEMFs reversed the doxorubicin resistance of the MOS/ADR1 cells by inhibiting P-gp function. The results suggested that PEMFs may be useful as a local treatment for MDR osteosarcoma.[9]

Finally, researchers explored the effects of pre-exposure to 50Hz to help to reduce resistance to 5-fluorouracil to enhance efficacy of the drug. The study explored the combined effect of 50 Hz-EMFs and 5-FU in the treatment of breast cancer. Researchers found that pre-exposure to 50 Hz-EMFs enhanced the antiproliferative effect of 5-FU in breast cancer cell line MCF-7 in a dose-dependent manner but did not affect normal human breast epithelial cell lines. They concluded that the enhanced cytotoxic activity of 5-FU on MCF7 cells through promoting entry into the S phase of the cell cycle via exposure to 50 Hz-EMFs, may provide a novel method of cancer treatment based on the combinatorial use of 50 Hz-EMFs and chemotherapy.[10]

The above studies indicated that ELF-EMFs and frequency therapy could potentially offer a novel approach to combatting drug resistant drug resistant conditions through the addition of frequency therapy as an adjuvant therapy in conjunction with conventional medication.

PEMF therapy for Drug Resistant Conditions – Safety, cost, implementation and monitoring of frequency therapy in drug resistant conditions

Naturally, before any therapy could be considered as an adjuvant therapy for any condition, it is imperative to examine the safety aspects of the proposed therapy.

Frequency therapy in the form of ELF-EMF, TENS and PEMF have been studied across a wide range of conditions for decades. There are even studies indicating that PEMF therapy for drug resistant cancers may be a viable option. For more information on that read “Pemf therapy for drug resistant cancer.”

These studies provide us with some information on the safety concerns and considerations for PEMF therapy for drug resistant conditions. Studies we have gathered over the years indicate that PEMF and frequency therapy have an exemplary safety profile with thousands of studies concluding no adverse effects from the therapy and minimal side effects associated with this type of treatment.

Dr Pawluk, an authority on PEMF therapy had the following remarks regarding the safety of PEMF therapy:

“There are only a few FDA-approved PEMF systems on the market. The primary mandate of the FDA is to ensure safety – even before proving efficacy of treatment. So keeping that in mind, we can examine the treatment parameters for one such FDA-approved PEMF system, the NeuroStar. This system (which uses the acronym TMS – transcranial magnetic stimulation – instead of PEMF) is indicated for Major Depressive Disorder and is an extremely high intensity system with stimulation aimed directly at the brain. NeuroStar systems produce intensities comparable to those of an MRI machine. …. Average treatment sessions last for 45 minutes. In NeuroStar clinical trials, more than 10,000 treatments were administered with no occurrence of adverse side effects.

So, this is extremely high intensity PEMF therapy applied directly to the head, and it is proven to be safe. These intensities are much higher than those of most commercially-available PEMF systems.”

With regards to seizures, Dr Pawluk states that:

“As long as I’ve been working with PEMFs there has always been a concern that PEMFs may cause seizures. There is now a fairly large body of research regarding the use of PEMFs of different intensities and the potential association with seizures. Evidence indicates that PEMFs are very unlikely to cause seizures. This is comes from research studies using high-intensity PEMF systems, which have the highest concern for generating seizure activity. In fact, studies that not only are PEMFs not at all likely to induce a seizure, they are capable of providing benefit to epileptic patients”[11]

Considering the safety profile of ELF-EMF therapy, the other considerations that need to be taken into account include the cost, implementation and monitoring of PEMF therapy for drug resistant conditions.

PEMF therapy for Drug Resistant Conditions – Cost and implementation of PEMF therapy

The current Rife PEMF Model MA200 can be used for the preliminary investigations to determine if this type of therapy can provide the benefits outlined above of reduced treatment duration and combatting drug resistance.

The stainless-steel cylinders that are provided with the device make implementation of the therapy simple and they provide the opportunity to sterilize equipment between patients, to reduce the chances of cross-contamination.

The Model MA200 can be rented for R499 per month, making it a cost-effective addition to therapy.

PEMF therapy for Drug Resistant Conditions – Conclusion

Frequency therapy has been shown to offer bactericidal effects, it has also been shown to help enhance antibiotic efficacy, and it has been shown to combat drug resistance. PEMF therapy for drug resistant conditions could therefore be helpful as an additional therapy option.

South Africa has been shown to take the lead in drug resistant conditions therapy by implementing mass roll out of bedaquiline to help combat drug resistant TB. The addition of frequency therapy to the drug resistant conditions treatment regimen may also be a world-first if it is shown to improve the treatment outcomes of drug resistant conditions.

The technology is locally owned, developed and produced providing South Africa with a huge potential advantage in the fight against multidrug resistant drug resistant conditions and potentially allowing South Africa to be a true leader in the fight against drug resistant conditions locally and perhaps even globally.

If investigations are successful, PEMF therapy for drug resistant conditions could be a reality in the near future.

[1] http://www.samj.org.za/index.php/samj/article/view/5102/3367

[2] https://doi.org/10.1080/15368370500379715

[3] https://www.ncbi.nlm.nih.gov/pubmed/21401315

[4] https://www.tandfonline.com/doi/full/10.1080/09205071.2014.974684?scroll=top&needAccess=true

[5] https://doi.org/10.1002/bem.20479

[6] https://www.ncbi.nlm.nih.gov/pubmed/?term=20033173

[7] https://www.ncbi.nlm.nih.gov/pubmed/12793569

[8] https://www.ncbi.nlm.nih.gov/pubmed/21437921

[9] https://www.ncbi.nlm.nih.gov/pubmed/11299755

[10] https://www.ncbi.nlm.nih.gov/pubmed/29617363

[11] https://www.drpawluk.com/education/pemf-information/pemf-safety/


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PEMF therapy for drug resistant cancer

PEMF therapy for drug resistant cancer

PEMF therapy for drug resistant cancer may soon be a reality. Cancer therapies are often presented to the patients in a Hobson’s choice type of approach. They either follow conventional therapy or alternative therapies which often feel like an impossible choice, particularly when most people when faced with a life-threatening condition, would choose to do everything they possibly can. Now cancer patients don’t have to make a choice between chemotherapy and PEMF therapy.

PEMF therapy for drug resistant cancer

For the first time the FDA has approved the use of tumor treating fields for the treatment of some types of brain cancer in conjunction with surgery, chemotherapy and radiation.[1]

There have been major strides in studying the effects of electric and magnetic fields in the possible treatment of cancer over the last few years. Some of these studies were outlined in our article “Pemf in cancer therapy – Pemf could be a promising modality.” Most of these studies have focused on the use of low frequency therapy as a treatment modality on its own, but now there are studies that indicate that a combination of PEMF and chemotherapy could be an excellent option for cancer patients, particularly those with chemo-resistant cancers.

With the emergence of drug resistant and multidrug resistant cancers, scientists have been frantically searching for ways to re-sensitize cancers to drugs which offer some hope for cancer patients. Enhancing the effects of chemotherapy drugs like cisplatin, doxorubicin, daunorubicin, 5-fluorouracil (Adrucil) and mitomycin C and the ability re-sensitize cancer cells to these drugs, may offer a novel approach to cancer therapy and new treatment options for cancer patients who have developed drug resistance.

In summary, studies have found that:

  • PEMF sensitized fibrosarcoma and hepatocellular carcinoma to mitomycin C
  • Low frequency EMF sensitized cisplatin-resistant ovarian adenocarcinoma
  • Pulsed magnetic fields enhanced the potency of daunorubicin in human carcinoma cell lines
  • PEMF improved the effects of doxorubicin in Osteosarcoma
  • 50Hz low frequency exposure enhanced the antiproliferative effects of 5-fluorouracil in breast cancer

The great news is that not only did PEMF therapy support and promote the efficacy of chemotherapy, but PEMF has already been approved as a pain therapy and the MA200 is an approved medical device in South Africa. PEMF therapy has also been shown to have an excellent safety profile with almost no adverse events being reported in thousands of clinical trials on pain and other conditions.

Adding PEMF therapy to a cancer and chemotherapy protocol poses very few, if any risks at all, and can provide numerous benefits for a cancer patient. The frequencies used in the studies are all available on the MA200. Finally, PEMF therapy is a cost-effective therapy for the cancer patient, with options from as little as R499 per month for the rental of an MA200 device.

PEMF therapy for drug resistant cancer - Summary of Studies

The following are summaries of the studies mentioned above, with references to those studies on Pubmed.

PEMF therapy for drug resistant cancer - PMF sensitized fibrosarcoma and hepatocellular carcinoma to mitomycin C

An article published in the Japanese Journal of Cancer research, investigated the effects of PMF therapy in combination with mitomycin C for the treatment of fibrosarcoma and hepatocellular carcinoma.[2]

WKA rats were exposed to a frequency of 200Hz immediately after IV injections of mitomycin C. The survival rates of the rats were recorded. Cultured cells were also used to study the efficacy of PMF and mitomycin C, and a combination of the two.

Survival rates of the untreated rats were 0% in the non-treated group, 34% in the group treated with mitomycin C only, and 47% for the PMF only group. For the group who received a combination of PMF and mitocycin C, the survival rate was 77%. The combination increased lifespan of the PMF mitomycin C group which was significantly prolonged at 17,6%. The efficiencies of the cells in the cultures of both cell lines were also significantly suppressed in the combination therapy group when compared with those in the other single therapy groups.

This study clearly indicates the possibility that PEMF therapy could improve and enhance the efficacy of drugs like mitomycin C.

PEMF therapy for drug resistant cancer - Low frequency EMF sensitizes cisplatin-resistant ovarian adenocarcinoma

Platinum based drugs like cisplatin often form the first line of therapy for cancers including testicular, bladder, esophageal cancer, lung cancer, mesothelioma, brain tumors, neuroblastoma ovarian and colorectal tumors but the use of cisplatin also often results in chemotherapy resistant cancers.[3]

In the search for a way to re-sensitize cancers to cisplatin, researchers investigated the use of extra-low frequency electromagnetic field therapy on cisplatin-resistant A2780 ovarian cancer cells. Cells were exposed to 200hz at 50 Gauss.

Researchers found that EL-EMF decreased proliferation of the cells independently of cisplatin. They also saw a decreased proliferation rate of 40 % in the cisplatin only group but the cells treated with a combination of cisplatin and EL-EMF showed a 71 % decrease in viability in rats.[4] They also saw a large increase in late apoptosis in the combination group as indicated in the graph below:

Histogram from percentage of live and dead cells from AO/PI staining for A2780 cells, data are presented as means (±SD)

The study concluded that EL-EMF therapy at 200Hz can help to sensitize cancer cells to cisplatin and improved the efficacy of cisplatin.

PEMF therapy for drug resistant cancer - Pulsed magnetic fields enhance the potency of daunorubicin in human carcinoma cell lines

Researchers studied the effects of PMF pulses of 250Hz on multidrug resistant human carcinoma cells. They inoculated mice with a multidrug resistant form of human carcinoma. They then treated the resultant tumors with pulsed magnetic therapy only or a combination of PMF therapy and daunorubicin.

Researchers found that amongst the various groups, significant differences in the tumor volume were found between PMF + saline and PMF + daunorubicin groups at 39 days and 42 days. No mice died in the PMF alone group, and no toxicity attributable to PMF was found during the experimental period.

The results indicated that the efficacy of daunorubicin was potentiated in vitro by PMF exposure when PMF exposure occurred in the presence of the drug.[5]

PEMF therapy for drug resistant cancer - PEMF improves the effects of doxorubicin in Osteosarcoma

In another study, researchers studied the potential drug resistance modification effects of PEMF stimulation in multidrug resistant mouse osteosarcoma. PEMF stimulation reversed doxorubicin resistance. The concluded that PEMFs reversed the doxorubicin resistance of the MOS/ADR1 cells by inhibiting P-gp function. The results suggested that PEMFs may be useful as a local treatment for multidrug resistant osteosarcoma.[6]

PEMF therapy for drug resistant cancer - 50Hz enhances the antiproliferative effects of 5-fluorouracil in breast cancer

Finally, researchers explored the effects of pre-exposure to 50Hz to help to reduce resistance to 5-fluorouracil to enhance efficacy of the drug. The study explored the combined effect of 50 Hz-EMFs and 5-FU in the treatment of breast cancer.

Researchers found that pre-exposure to 50 Hz-EMFs enhanced the antiproliferative effect of 5-FU in breast cancer cell line MCF-7 in a dose-dependent manner but did not affect normal human breast epithelial cell lines.

They concluded that the enhanced cytotoxic activity of 5-FU on MCF7 cells through promoting entry into the S phase of the cell cycle via exposure to 50 Hz-EMFs, may provide a novel method of cancer treatment based on the combinatorial use of 50 Hz-EMFs and chemotherapy.[7]

[1] http://www.bendwellnessdoctor.com/index.php?p=513073

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918102/

[3] https://www.ncbi.nlm.nih.gov/pubmed/21892204

[4] https://www.ncbi.nlm.nih.gov/pubmed/26370097

[5] https://www.ncbi.nlm.nih.gov/pubmed/9216668

[6] https://www.ncbi.nlm.nih.gov/pubmed/11299755

[7] https://www.ncbi.nlm.nih.gov/pubmed/29617363


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TENS for Multiple Sclerosis

Although the underlying cause of this debilitating condition is still unknown, PEMF therapy and TENS for Multiple Sclerosis offer some hope for MS patients. Often dealing with the symptoms of the disease, there are many interesting studies that examine the use of electrotherapy for the management of various symptoms experienced by Multiple Sclerosis patients.

These studies deal with the effects of EMF therapy as well as TENS and tDCS. They address a diverse range of concerns for MS patients like myelin sheath repair, reduction in fatigue, decreases in pain, improvement of nerve reorganization and decreases in spasticity.

These symptoms can severely impair the quality of life of an MS patient, and electrotherapy in the form of TENS therapy for multiple sclerosis offers a non-pharmaceutical based, therapy alternative with virtually no reported adverse effects for this type therapy. TENS is even listed as one of the accepted therapies by the MS Trust in the UK and other MS organizations.

TENS for Multiple Sclerosis

Current Studies on TENS for Multiple Sclerosis include:

The parameters of these studies are not dissimilar to the outputs of the Rife Model MA device. Since the underlying cause of Multiple Sclerosis is not yet known, therapies aimed at improving the symptoms are currently a good indication of how to approach therapy in cases of MS.

For the Rife Model MA protocol for MS, click here.

To reserve your Rife Model MA200 from just R499 per month, contact us today.


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PEMF for Multiple Sclerosis – The Protocol

There are a number of interesting studies that deal with the use of TENS and PEMF for Multiple Sclerosis patients. These studies deal with the effects of EMF therapy as well as TENS and tDCS. The parameters of these studies are not dissimilar to the outputs of the Rife Model MA device. Since the underlying cause of multiple sclerosis is not yet known, therapies aimed at improving the symptoms are currently the best indication of how to approach therapy in cases of MS. To read more about PEMF and TENS for Multiple Sclerosis, click here.

PEMF for Multiple Sclerosis

TENS and PEMF for Multiple sclerosis studies on MS include:

TENS therapy is even listed as one of the accepted therapies by the MSTrust in the UK.

The following protocol takes into account some of the studies on Multiple Sclerosis and is based on practical usage by practitioners using the Model MA for multiple sclerosis. The protocol is merely an idea of what programs could be beneficial for this condition.

Please consider using the suggesting programs and creating your own protocol that suits your patients or your own lifestyle needs. Some programs may provide more relief than others. Please feel free to adjust the protocol for these circumstances.

PEMF for Multiple sclerosis - The Protocol

Multiple Sclerosis – At least 3 to 6 times a week
Circulation – Three times a week
Inflammation – Three times a week
Nerve and nervous disorders  – Three times a week
Relaxation and Meditation – Twice a week – to promote muscle relaxation
Detox and Lymph drainage – At least once a week
Sleep/Schumann – Every night to support healing and sleep
Pain frequencies as necessary to manage specific types of pain

Create a schedule that suits your lifestyle using longer programs on the days you have more time and shorter ones on busier days.

 

  Monday Tuesday Wednesday Thursday Friday Saturday Sunday
Daytime Multiple Sclerosis

Inflammation
Circulation

Nerve and nervous disorders

Multiple Sclerosis

Nerve and nervous disorders
Multiple Sclerosis

Inflammation

Circulation

Nerve and nervous disorders

Circulation

 

Inflammation

Multiple Sclerosis

Detox and Lymph drainage

Overnight Schumann Schumann Schumann Schumann Schumann Schumann Schumann
Additional – if necessary Pain Pain Pain Pain Pain Pain Pain

 

 


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PEMF therapy for Carpal Tunnel Syndrome

An interesting study on PEMF therapy for Carpal Tunnel Syndrome was published recently in the Journal of Advanced Research. The double-blind trial compared the efficacy of pulsed ultrasound with pulsed electromagnetic therapy for the treatment of postnatal carpal tunnel syndrome and found that PEMF improved grip strength, reduced pain and could be an effective therapy for patients with Carpal Tunnel Syndrome. The study included 40 patients diagnosed with carpal tunnel syndrome.

The study ran for four weeks during which time patients were given exercises to help to improve the condition and groups of patients received either pulsed ultrasound therapy or PEMF therapy three times a week for four weeks. The patients received PEMF therapy at 50Hz for 30 minutes per session. 50Hz on the Rife Model MA and UA devices is frequency number 297 and there is a Carpal Tunnel Syndrome program on both the Rife Model MA and UA.

PEMF therapy for Carpal Tunnel Syndrome Research - Outcome of the Study

The study measured pain levels, sensory and motor distal latencies, hand grip strength and conduction velocities of the median nerve. After therapy, the groups who received therapy showed significant improvement in all of the areas measured. There was also a difference between the two groups, with the group who received PEMF therapy showing more improvement than the group who received pulsed ultrasound therapy.

Since the symptoms of Carpal Tunnel Syndrome include pain, inflammation and discomfort, it should not really be surprising to show improvements in these areas since both TENS and PEMF have been shown to help reduce pain, increase circulation and decrease inflammation.

It is also important to note that no adverse side effects were reported for either PEMF or ultrasound therapy. Unlike pain medication and non-steroidal anti-inflammatory drugs, the use of PEMF therapy for Carpal Tunnel Syndrome could offer a drugless alternative to the current pharmaceutical treatments available.

For more information on PEMF and TENS therapy and inflammation, you can read our article on TENS therapy for Inflammation.

For Rife PEMF protocols, please read: Rife PEMF Protocol for Sinusitis

You can purchase a Rife Model MA200 on our rent to buy program at only R499.00 per month. Contact us today for more information at info@pemf.co.za or via whatsapp on 082 888 3223.

PEMF therapy for Carpal Tunnel Syndrome

 


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PEMF therapy for drug resistant cancer

PEMF in cancer therapy – PEMF could be a promising modality

More and more studies are showing beneficial effects of PEMF in areas like oncology and the benefits of TENS and PEMF therapy in these areas are no longer limited to pain control and management. PEMF in cancer therapy may be a reality in the near future. There are also studies that PEMF can help to overcome some drug resistance in cancer. To read, PEMF THERAPY FOR DRUG RESISTANT CANCER, click here.

PEMF in Cancer therapy

PEMF therapy has been shown to reduce inflammation

A recent review published in Cancer Medicine investigates the use of PEMF in cancer therapy. It investigates PEMF therapy in vitro, in vivo and human clinical studies that have focused on PEMF in oncology and the study concludes that “studies show that PEMF therapy is safe and promising compared to other available cancer therapies. In the future, PEMFs could be used not only as primary therapy but also in combination with other common antineoplastic therapies.”

PEMF in Cancer Therapy - Cancer's included in the Review

Studies included in the review focused on breast cancer therapy, colon cancer, liver cancer and melanoma.

One of the studies on breast cancer cells found that treatment selectively caused MCF7 cells to commit suicide but did not affect MCF10 cells in other words it caused cancer cells to die but did not affect normal breast cells. Another study found that PEMF therapy in mice daily resulted in a 30% to 70% breast tumor reduction and PEMF therapy for 360 minutes daily suppressed tumor growth at week 4 of therapy.

In one of the clinical trials, PEMF therapy was offered to 28 patients with advanced cancer including breast cancer, ovarian cancer, pancreatic cancer, colorectal cancer, glioblastoma and HCC carcinoma. None of the patients reported any side effects and four patients reported stable disease including a patient with thyroid cancer with biopsy-proven lung metastases, a patient diagnosed with mesothelioma metastatic to the abdomen, a patient with non-small-cell lung cancer and a patient with pancreatic cancer with biopsy-proven liver metastases.

To read the review on PEMF in cancer therapy, click here.


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